Immunology 415: Immunology Journal

Week of 11/20/20 1. Anaphylaxis : IgE mediated hypersensitivity reaction. It is an almost immediate response triggered by antigenic challenge. When this reaction occurs, it is accompanied by a release in histamines and other agents which cause leakage of the capillary, wheezing, cyanosis, edema of the larynx, tongue, lips, and eyelids. This can trigger a drop in blood pressure and if not treated immediately, death.  1594016374_Anaphylaxis_big_600.jpg 2. Interferon: groups of cytokines that induce an antiviral state or regulate immune responses. Also, one of the first to become active in the immune response; inhibits viral replication.  https://medium.com/covid-19-collection/covid19-interferons-predicting-deathly-cases-6e39a591525a 3. Proteolytic : the ability to break down protein molecules; catalyzed by protease enzyme.  https://www.researchgate.net/figure/Schematic-view-of-the-mechanism-of-proteolysis-of-a-globular-protein_fig1_8488848

  Week of 11/6/20 This week since our case study had more to do with IgA deficiency, which is a topic we briefly went over in class, I wanted to further expound on my research. Specifically, I wanted to figure out the4 pathophysiology of how this disease comes about. Since IgA is one of the various subtypes of antibodies, it plays a huge role in fighting off bacterial infections. In my research, those with IgA immunodeficiency typically respond well to vaccines. Those with this deficiency may be symptomatic or asymptomatic. Although, a large majority are typically asymptomatic which is why the disease may go undetected for so long. As we know, it IgA is the second most common antibody and is found on mucosal barriers such as the respiratory and digestive tracts. In addition to being found in saliva, tears, and breastmilk. In infants, breastmilk provides a defense mechanism against infections in the early stages of their life. Furthermore, as I got deeper in my research it was found tha